They collectively serve as the successor to the Samsung Galaxy S21 series. The first three smartphones were unveiled at Samsung's Galaxy Unpacked event on 9 February 2022.

The S22 series consists of the base Galaxy S22 model, the plus Galaxy S22+ model, and the camera-note-focused Galaxy S22 Ultra model. The S22 Ultra serves as the official successor to the Samsung Galaxy Note20 series and Note lineup, housing an integrated S-pen. There are numerous upgrades the phones possess over the previous models, in addition to improved specifications, an enhanced camera system supporting 8K video recording (7680×4320) at 24 frames per second, and a super-resolution zoom of 30–100x, for the Ultra model.